The Internet of Things offers huge potential for the healthcare sector – ranging from diagnostics to patient safety and optimized logistical processes. A total of 21 European partners are involved in the project SERENE IoT, which aims to lay the foundations for IoT applications in healthcare. Within the scope of this project, the German consortium under the coordination of Fraunhofer EMFT is developing an IoT-capable mobile analysis device to detect multi-resistant Staphylococcus aureus (MRSA). The detection method (developed in the project MRE Test, funded by the Bavarian Ministry of Economic Affairs and Media, Energy and Technology as part of the »Mikrosystemtechnik Bayern« program, reference: MST-1308-0001//BAY189/001) is to be transfered to an overall system with connectivity capability which can run on batteries. The basis is provided by new application-specific memory chips with a very low level of energy consumption. The research project is focusing on the development of a secure software architecture for IoT networking of medical devices and the secure transfer of confidential data. The concept of IoT-networked medical devices is being tested nationally using various demonstrators (mobile MRSA detector, device to detect postoperative infections, food pump, fall detector to identify and prevent falls) by the hospital of Ludwig Maximilian University, Munich.