The principle of the physical measurement and all materials involved are selected carefully to ensure that the cells will not be affected in any way by the measurement itself. Either individual or combinations of transducers are integrated into cell culture vessels to monitor the cells contactless and with a tailored time resolution between milliseconds and days. Very different parameters of cell physiology are accessible under the influence of an external stimulus like the cells’ viability, their proliferation rate, their migration rate or changes in cell volume.
These cell-based sensors are applied in many different fields of science comprising fundamental problems of medical technology, drug and toxicity screening as well as regenerative medicine.
The team on Fraunhofer EMFT site Regensburg offers consulting about suitable transducer principles, selecting sensor materials, functionalization and integration of the sensors in individual experimental settings to data analysis, as well as proof-of-concept studies for special assay or sensor formats and technologies.